Program

São Paulo School of Advanced Science on “Medicines: from Target to Market”, together with the “Summer School on Medicines” 10th Edition (SSM10).

 March 16th-23rd, 2018.
Ribeirão Preto Medical School, University of São Paulo (FMRP/USP). Anfiteatro do Bloco Didático.

 

PROGRAM:

FRIDAY, March 16th – 2018

Venue: Ribeirão Preto Medical School, University of São Paulo (FMRP/USP). Anfiteatro do Bloco Didático.

REGISTRATION, OPENING & KEYNOTE LECTURES

14:00 – 16:00  Registration & Poster placing

16:00 – 16:15  OFFICIAL OPENING
Chair: The Organizing Committee

16:15 – 17:15  Keynote Opening Lecture 1 (KNL1)
Jordi Quintana, Universitat Pompeu Fabra, UPF, Barcelona, Spain.

17:15 – 18:00  Keynote Opening Lecture 2 (KNL2)
Luiz Nunes de Oliveira, Adjunct Coordinator of Special Programs at FAPESP, Sao Paulo, Brazil.

19:00 – 22:00 Welcome Reception (Hotel Pousada Santa Rita, Avenida do Café, 2295 – Ribeirão Preto)

SATURDAY, March 17th – 2018

Venue: Ribeirão Preto Medical School, University of São Paulo (FMRP/USP). Anfiteatro do Bloco Didático.

 SESSION I: DRUG R&D, AN OVERVIEW FROM IDEA TO MARKET
Chairperson: Jordi Quintana & Claudio Costa-Neto

09:30 – 10:30  (L1) Drug Discovery overview: from idea to drug candidate
Denis deBlois, Pharmacy Faculty Director, University of Montreal, Canada.

10:30 – 11:00  Coffee Break

11:00 – 11:30  (L2) Overview on Clinical trials
Denis deBlois, Pharmacy Faculty Director, University of Montreal, Canada.

11:30 – 12:30  (L3) Overview on Business Development
Steven Xanthoudakis, Merck Frosst Centre for Therapeutic Research, Montreal, Canada.

12:30 – 14:00  Lunch

SESSION II: TARGET-BASED DRUG DISCOVERY
Chairperson: Jordi Quintana & Claudio Costa-Neto

14:00 – 14:45  (L4) Chemical biology for Drug-Discovery
Jordi Quintana, Universitat Pompeu Fabra, UPF, Barcelona, Spain.

14:45 – 15:30  (L5) From basic to updated concepts in Drug-Discovery Pharmacology (I)
André S. Pupo, State University of Sao Paulo, UNESP, Botucatu, SP, Brazil

15:30 – 16:15 (L6) SR25, a Plasmodium falciparum GPCR, a new target for antimalarials
Celia R. S. Garcia, Biosciences Institute, University of São Paulo, Brazil

16:15 – 16:30  Coffee Break

16:30 – 17:15  (L7) Drug Design based on target structure
Xavier Deupi, Paul Scherrer Institute, Switzerland

17:15 – 17:45  (L8) Hands on: structure analysis and drug/target modeling
Xavier Deupi, Paul Scherrer Institute, Switzerland

17:45 – 18:30  (L9) Biophysical methods for target-based ligand screening in drug discovery
Maria Cristina Nonato, Ribeirao Preto School of Pharmacy, University of Sao Paulo, Brazil

SUNDAY, March 18th – 2018

Venue: Ribeirão Preto Medical School, University of São Paulo (FMRP/USP). Anfiteatro do Bloco Didático.

 SESSION III: ORAL PRESENTATIONS FROM PARTICIPANTS

09:00 – 10:30  Oral Presentations (The 3×3 Pitch: 3 slides in 3 minutes sharp)

10:30 – 11:00  Coffee Break

 SESSION IV: FROM DRUG DISCOVERY TO EARLY (PRE)CLINICAL DEVELOPMENT (PART I)
Chairperson: Denis DeBlois, Pierre Cordelier

11:00 – 12:30  (L10) ADME (Pharmacokinetics / Pharmacodynamics)
Sylvie Perreault, Faculty of Pharmacy, University of Montreal, Canada

12:30 – 14:00 Lunch

14:00 – 14:45  (L11) New classes of biological drugs: cell and gene therapy products
Pierre Cordelier, INSERM U1037, Toulouse Oncopole & University Paul Sabatier, Toulouse, France.

14:45 – 15:30  (L12) Drug Discovery of dendrimers: from discovery to creation of a startup
Rémy Poupot, CHU Purpan, University Paul Sabatier, Toulouse, France

15:30 – 16:15 (L13) (L5) From basic to updated concepts in Drug-Discovery Pharmacology (II)
André S. Pupo, State University of Sao Paulo, UNESP, Botucatu, SP, Brazil

 16:15 – 16:30  Coffee Break

16:30 – 17:15  (L14) Discovery and development of new GPCR biased drugs
Claudio Costa-Neto, Ribeirao Preto Medical School, USP, Brazil

 17:15 – 18:00  (L14) The Center for Research in Inflammatory Diseases (CRID): Structure and Scientific Strategies Illustrated by two Research Cases
Fernando Q. Cunha & Thiago M. Cunha

 18:00 – 19:00 Poster Discussion

MONDAY, March 19th – 2018

Venue: SUPERA Technological Park, Avenida Dra Nadir Águiar, 1805, Ribeirão Preto.

SESSION V: CASE STUDY IN DRUG DISCOVERY AND DEVELOPMENT
Chairperson: Denis DeBlois, Rémy Poupot, Pierre Cordelier

09:00 – 09:30  Case presentation and outline of challenges

09:30 – 10:30  Group session (students work in small teams)

10:30 – 11:00  Coffee Break

11:00 – 12:30  Each team reports / General discussion

12:30 – 14:00 Lunch

SESSION VI: FROM DRUG DISCOVERY TO EARLY (PRE)CLINICAL DEVELOPMENT (PART II)
Chairperson: Jordi Quintana, Universitat Pompeu Fabra, UPF, Barcelona, Spain.

14:00 – 14:45  (L15) Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with In Vivo Activity
Rafael V.C. Guido, University of Sao Paulo, Sao Carlos, Brazil

14:45 – 15:30  (L16) Toxicology / Preclinical Safety
Denis deBlois, Pharmacy Faculty Director, University of Montreal, Canada

15:30 – 16:15  (L17) Pre-Clinical Development
Pierre Cordelier, INSERM U1037, Toulouse Oncopole & University Paul Sabatier, Toulouse, France

 16:15 – 16:30  Coffee Break

16:30 – 18:00 Visit SUPERA Technological Park

TUESDAY, March 20th – 2018

Venue: Ribeirão Preto Medical School, University of São Paulo (FMRP/USP). Anfiteatro do Bloco Didático.

SESSION VII: START-UP CREATION, INVESTMENT & BUSINESS DEVELOPMENT
Chairperson: Jordi Quintana & Claudio Costa-Neto

09:00 – 09:45  (L18) Illustrative cases presented by an entrepreneur (I): From discovery to pharmaceutical development
Invited Speaker: Robson A. S. Santos, Professor at UFMG and founder of Labfar, Belo Horizone, MG, Brazil.

 09:45 – 10:30  (L19) Illustrative cases presented by an entrepreneur (II): Medical Devices
Invited Speaker: Jarbas Caiado de Castro Neto, Professor at USP/São Carlos and founder of Opto

10:30 – 11:00  Coffee Break

11:00 – 12:30  (L20)   Public-Private Partnership for Drug Discovery and Development
Jordi Quintana, Universitat Pompeu Fabra, UPF, Barcelona, Spain; and Steven Xanthoudakis, Merck Frosst Centre for Therapeutic Research in Montreal, Canada.

12:30 – 14:00 Lunch

 14:00 – 15:00  (L21) From scientist to entrepreneur: what does it take?
Xavier Barril, Institute of Biomedicine, University of Barcelona, Barcelona, Spain

15:00 – 16:00  (L22) The experience of Albert Einstein Hospital Supporting Innovation & Entrepreneurship in Healthcare
Claudio Terra, Director of Innovation, Albert Einstein hospital, São Paulo, Brazil

 16:00 – 16:30 Coffee Break

16:30 – 17:15  (L23) Start-up Creation, From the Bench to the Bedside, the journey of a faculty entrepreneur
Mark Kester, University of Virginia, USA

17:15 – 18:00 (L24) CNS disease modeling: from cause to treatment
Patrícia Beltrão Braga, ICB-II, Universidade de São Paulo, Brazil

WEDNESDAY, March 21st – 2018

Venue: Ribeirão Preto Medical School, University of São Paulo (FMRP/USP). Anfiteatro do Bloco Didático.

SESSION VIII: CLINICAL DEVELOPMENT & REGULATORY
Chairperson: Roger Chammas, School of Medicine, University of Sao Paulo, & Denis DeBlois, Pharmacy Faculty Director, University of Montreal, Canada.

09.00 – 9:45    (L25) Working with the FDA and other government agencies on Clinical Trials
Mark Kester, University of Virginia, USA

9:45 – 10:30    (L26) Benefit/risk assessment / Pharmacovigilance
Denis deBlois, Pharmacy Faculty Director, University of Montreal, Canada

10:30 – 11:00  Coffee Break

11:00 – 11:45  (L27) Pharmaco-economics
Sylvie Perreault, Faculty of Pharmacy, University of Montreal, Canada

11:45 – 12:30  (L28) “Beyond the pill”: Gene Editing and Ethical Concerns
Pierre Cordelier, INSERM U1037, Toulouse Oncopole & University Paul Sabatier, Toulouse, France

12:30 – 14:00  Lunch

 SESSION IX: MARKET ACCESS & INTELLECTUAL PROPERTY
Chairperson: Roger Chammas, School of Medicine, University of Sao Paulo, & Denis DeBlois, Pharmacy Faculty Director, University of Montreal, Canada.

14:00 – 14:45  (L29) Market access
Sylvie Perreault, Faculty of Pharmacy, University of Montreal, Canada

14:45 – 15:30  (L30) Intellectual Property

T.B.A.

15:30 – 16:15  (L31) Working with Universities on Intellectual Property and Start up Creations
Mark Kester, University of Virginia, USA

16:15 – 16:30 Coffee Break

16:30 – 19:00 Poster Discussion

THURSDAY, March 22nd – 2018

Venue: Ribeirão Preto Medical School, University of São Paulo (FMRP/USP). Anfiteatro do Bloco Didático.

 SESSION X: CASE STUDY IN INTELLECTUAL PROPERTY
Chairperson: Jordi Quintana, Rémy Poupot, Pierre Cordelier

09:00 – 10:30  Case presentation and outline of challenges

10:30 – 11:00  Coffee Break

11:00 – 12:30  Group session (students work in small teams)

12:30 – 14:00 Lunch

 14:00 – 15:30  Each team reports / General discussion

 15:30 – 18:00  Visit Laboratories at University of Sao Paulo Campus

FRIDAY, March 23rd – 2018

Venue: Ribeirão Preto Medical School, University of São Paulo (FMRP/USP). Anfiteatro do Bloco Didático.

 SESSION XI: CAREERS & PERSPECTIVES IN LIFE SCIENCES

09:00 – 10:30  (L32) Careers in Life Sciences
Panel composed by members of the Organizing Committee & Invited Speakers.

10:30 – 11:00  Coffee Break

 11:00 – 11:45 (L33) Establishing a Biopharmaceutical Industry in Brazil – challenges and opportunities
Thiago Mares Guia, Bionovis, São Paulo, Brazil.

11:45 – 12:30 (L34) Broadening the horizons: Systems Biology as an approach to identify problems and possible solutions
Helder Nakaya, Faculty of Pharmaceutical Sciences, USP, São Paulo.

 12:30 – 14:00  Lunch

SESSION XII: KEYNOTE LECTURES & CLOSING SESSION
Chair: The Organizing Committee

14:00 – 15:00  (KNL3) – Keynote Closing Lecture 3. Illustrative cases presented by an entrepreneur (IV): Foundation and development of Recepta Biopharma
Invited Speaker: Fernando Perez, former Professor at USP and founder of Recepta Biopharma.

 15:00 – 16:00  (KNL4) – Keynote Closing Lecture 4.
Michel Bouvier, Department of Biochemistry, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Canada.

16:00 – 16:15  SSM10 Evaluation / Final Discussion

16:15 – 16:30  SSM10 closing remarks and pre-launching of SSM11 in Montreal, Canada.

16:30 – 17:00  Farewell Coffee Break

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